Title: Intercomparison of 99mTc, 18F and 111In activity measurements with radionuclide calibrators in Belgian hospitals
Authors: SALDARRIAGA VARGAS C.RODRIGUEZ PEREZ S.BAETE K.POMME STEFAANPAEPEN JANVAN AMMEL RAFSTRUELENS L.
Citation: PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS vol. 45 p. 134-142
Publisher: ELSEVIER SCI LTD
Publication Year: 2018
JRC N°: JRC108466
ISSN: 1120-1797
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC108466
DOI: 10.1016/j.ejmp.2017.12.011
Type: Articles in periodicals and books
Abstract: This study presents current status of performance of radiopharmaceutical activity measurements using radionuclide calibrators in Belgium. An intercomparison exercise was performed among 15 hospitals to test the accuracy of 99mTc, 18F and 111In activity measurements by means of radionuclide calibrators. Four sessions were held in different geographical regions between December 2013 and February 2015. The data set includes measurements from 38 calibrators, yielding 36 calibrations for 99mTc and 111In, and 21 calibrations for 18F. For each radionuclide, 3 ml of stock solution was measured in two clinical geometries: a 10 ml glass vial and a 10 ml syringe. The initial activity was typically 100 MBq for 99mTc, 15 MBq for 111In and 115 MBq for 18F. The reference value for the massic activity of the radioactive solutions was determined by means of primary and secondary standardisation techniques at the radionuclide metrology laboratory of the JRC. The overall results of the intercomparison were satisfactory for 99mTc and 18F, since most radionuclide calibrators (>70%) were accurate within ±5% of the reference value. Nevertheless, some devices underestimated the activity by 10–20%. Conversely, 111In measurements were strongly affected by source geometry effects and this had a negative impact on the accuracy of the measurements, in particular for the syringe sample. Large overestimations (up to 72%) were observed, even when taking into account the corrections and uncertainties supplied by the manufacturers for container effects. The results of this exercise encourage the hospitals to perform corrective actions to improve the calibration of their devices where needed.
JRC Directorate:Nuclear Safety and Security

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