Title: Commutability of the certified reference materials for the standardization of β-amyloid 1-42 assay in human cerebrospinal fluid: lessons for tau and β-amyloid 1-40 measurements
Authors: ANDREASSON ULFKUHLMANN JULIAPANNEE JOSEFUMEK ROBERTSTOOPS ERIKVANDERSTICHELEN HUGOMATZEN ANJAVANDIJCK MANUDAUWE MARTINELEINENBACH ANDREASRUTZ SANDRAPORTELIUS ERIKZEGERS INGRIDZETTERBERG HENRIKBLENNOW KAJ
Citation: CLINICAL CHEMISTRY AND LABORATORY MEDICINE vol. 56 no. 12 p. 2058–2066
Publisher: WALTER DE GRUYTER GMBH
Publication Year: 2018
JRC N°: JRC108513
ISSN: 1434-6621 (online)
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC108513
DOI: 10.1515/cclm-2018-0147
Type: Articles in periodicals and books
Abstract: The core Alzheimer’s disease cerebrospinal fluid (CSF) biomarkers total tau (T-tau), phosphorylated tau (P-tau), β-amyloid 1-42 (Aβ42) and β-amyloid 1-40 (Aβ40) are increasing in importance and are now part of the research criteria for the diagnosis of the disease. The main aim of this study is to evaluate whether a set of certified reference materials (CRMs) are commutable for Aβ42 and to serve as a feasibility study for the other markers. This property is a prerequisite for the establishment of CRMs which will then be used by manufacturers to calibrate their assays against. Once the preanalytical factors have been standardized and proper selection criteria are available for subject cohorts this harmonization between methods will allow for universal cut-offs to be determined.
JRC Directorate:Health, Consumers and Reference Materials

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