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|Title:||Commutability of the certified reference materials for the standardization of β-amyloid 1-42 assay in human cerebrospinal fluid: lessons for tau and β-amyloid 1-40 measurements|
|Authors:||ANDREASSON ULF; KUHLMANN JULIA; PANNEE JOSEF; UMEK ROBERT; STOOPS ERIK; VANDERSTICHELEN HUGO; MATZEN ANJA; VANDIJCK MANU; DAUWE MARTINE; LEINENBACH ANDREAS; RUTZ SANDRA; PORTELIUS ERIK; ZEGERS INGRID; ZETTERBERG HENRIK; BLENNOW KAJ|
|Citation:||CLINICAL CHEMISTRY AND LABORATORY MEDICINE vol. 56 no. 12 p. 2058–2066|
|Publisher:||WALTER DE GRUYTER GMBH|
|Type:||Articles in periodicals and books|
|Abstract:||The core Alzheimer’s disease cerebrospinal fluid (CSF) biomarkers total tau (T-tau), phosphorylated tau (P-tau), β-amyloid 1-42 (Aβ42) and β-amyloid 1-40 (Aβ40) are increasing in importance and are now part of the research criteria for the diagnosis of the disease. The main aim of this study is to evaluate whether a set of certified reference materials (CRMs) are commutable for Aβ42 and to serve as a feasibility study for the other markers. This property is a prerequisite for the establishment of CRMs which will then be used by manufacturers to calibrate their assays against. Once the preanalytical factors have been standardized and proper selection criteria are available for subject cohorts this harmonization between methods will allow for universal cut-offs to be determined.|
|JRC Directorate:||Health, Consumers and Reference Materials|
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