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|Title:||Are existing standard methods suitable for the evaluation of nanomedicines: some case studies.|
|Authors:||GIORIA SABRINA; CAPUTO FANNY; URBAN LOPEZ PATRICIA; CIARAN MANUS MAGUIRE; BREMER SUSANNE; PRINA-MELLO ADRIELE; CALZOLAI LUIGI; MĖHN DÓRA|
|Citation:||NANOMEDICINE vol. 13 no. 5|
|Publisher:||FUTURE MEDICINE LTD|
|Type:||Articles in periodicals and books|
|Abstract:||The use of nanotechnology in medical products has been demonstrated at laboratory scale, and many resulting nanomedicines are in the translational towards clinical applications, with global market trends indicating strong growth of the sector in coming years. The translation of nanomedicines towards the clinic and subsequent commercialisation may requires the development of new or adaptation of existing standards to ensure the quality, safety, and efficacy of such products. This work addresses some identified needs, and illustrates the shortcomings of currently used standardised methods when applied to medical-nanoparticles to assess particle size, drug loading, drug release and in vitro safety. Alternative physicochemical, and in vitro toxicology methods, with potential to qualify as future standards supporting the evaluation of nanomedicine are provided.|
|JRC Directorate:||Health, Consumers and Reference Materials|
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