Title: Standardisation of autoimmune testing - is it feasible?
Authors: MONOGIOUDI EVANTHIAMARTOS SEVILLA GUSTAVOPETRONELA HUTU DANASCHIMMEL HEINZMERONI PIERLUIGISHELDON JOANNAZEGERS INGRID
Citation: CLINICAL CHEMISTRY AND LABORATORY MEDICINE vol. 56 no. 10 p. 1734–1742
Publisher: WALTER DE GRUYTER GMBH
Publication Year: 2018
JRC N°: JRC110987
ISSN: 1434-6621 (online)
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC110987
DOI: 10.1515/cclm-2017-1077
Type: Articles in periodicals and books
Abstract: Correct measurement of autoantibodies is essential for the diagnosis of autoimmune diseases. However, due to the variability of autoantibody results and the heterogeneity of testing, wrong diagnosis is a reality. For this and more reasons, harmonisation of testing is of the outmost importance. In this review we have summarised the factors contributing to this variability. The ways with which the working group on Harmonisation of Autoantibody testing of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has been trying to tackle the issue with the production and correct use of Certified Reference Materials (CRMs), is being discussed. Finally the advantages and the limitations of the use of CRMs are presented.
JRC Directorate:Health, Consumers and Reference Materials

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