Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates
In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.
YASINSKA Inna;
CECCONE Giacomo;
OJEA JIMENEZ Isaac;
PONTI Jessica;
HUSSAIN Rohanah;
SILIGARDI Giuliano;
BERGER Steffen M.;
FASTER-KAN Elizaveta;
BARDELLI Marco;
VARANI Luca;
FIEDLER Walter;
WELLBROCK Jasmin;
RAPP Ulrike;
GIBBS Bernhard;
CALZOLAI Luigi;
SUMBAYEV Vadim;
2018-07-11
ROYAL SOC CHEMISTRY
JRC111171
2040-3364,
http://pubs.rsc.org/en/Content/ArticleLanding/2018/NR/C7NR09436A#!divAbstract,
https://publications.jrc.ec.europa.eu/repository/handle/JRC111171,
10.1039/c7nr09436a,
Additional supporting files
| File name | Description | File type | |
|---|
