Title: Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates
Authors: YASINSKA INNACECCONE GIACOMOOJEA JIMENEZ ISAACPONTI JESSICAHUSSAIN ROHANAHSILIGARDI GIULIANOBERGER STEFFEN M.FASTER-KAN ELIZAVETABARDELLI MARCOVARANI LUCAFIEDLER WALTERWELLBROCK JASMINRAPP ULRIKEGIBBS BERNHARDCALZOLAI LUIGISUMBAYEV VADIM
Citation: NANOSCALE vol. 10 no. 13 p. 5827-5883
Publisher: ROYAL SOC CHEMISTRY
Publication Year: 2018
JRC N°: JRC111171
ISSN: 2040-3364
URI: http://pubs.rsc.org/en/Content/ArticleLanding/2018/NR/C7NR09436A#!divAbstract
http://publications.jrc.ec.europa.eu/repository/handle/JRC111171
DOI: 10.1039/c7nr09436a
Type: Articles in periodicals and books
Abstract: In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.
JRC Directorate:Health, Consumers and Reference Materials

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