Title: Current EU research activities on combined exposure to multiple chemicals
Authors: BOPP STEPHANIEBAROUKI ROBERTBRACK WERNERDALLA COSTA SILVIADORNE JEAN-LOUDRAKVIK ELINAFAUST MICHAELKARJALAINEN TUOMOKEPHALOPOULOS STYLIANOSVAN KLAVEREN JACOBKOLOSSA-GEHRING MARIKEKORTENKAMP ANDREASLEBRET ERIKLETTIERI TERESANORAGER SOFIERUEGG JOELLETARAZONA JOSEVAN DE WATER BOBTRIER XENIAVAN GILS JOSBERGMAN AKE
Citation: ENVIRONMENT INTERNATIONAL vol. 120 p. 544–562
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication Year: 2018
JRC N°: JRC111809
ISSN: 0160-4120
URI: https://www.sciencedirect.com/science/article/pii/S0160412018308420?via%3Dihub
http://publications.jrc.ec.europa.eu/repository/handle/JRC111809
DOI: 10.1016/j.envint.2018.07.037
Type: Articles in periodicals and books
Abstract: Humans and wildlife are exposed to an intractably large number of different combinations of chemicals via food, water, air, consumer products, and other media and sources. This raises concerns about their impact on public and environmental health. The risk assessment of chemicals for regulatory purposes mainly relies on the assessment of individual chemicals. If exposure to multiple chemicals is considered in a legislative framework, it is usually limited to chemicals falling within this framework and co-exposure to chemicals that are covered by a different regulatory framework is often neglected. Methodologies and guidance for assessing risks from combined exposure to multiple chemicals have been developed for different regulatory sectors, however, a harmonised, consistent approach for performing mixture risk assessments and management across different regulatory sectors is lacking. At the time of this publication, several EU research projects are running, funded by the current European Research and Innovation Programme Horizon 2020 or the Seventh Framework Programme. They aim at addressing knowledge gaps and developing methodologies to better assess chemical mixtures, by generating and making available internal and external exposure data, developing models for exposure assessment, developing tools for in silico and in vitro effect assessment to be applied in a tiered framework and for grouping of chemicals, as well as developing joint epidemiological-toxicological approaches for mixture risk assessment and for prioritising mixtures of concern. The projects EDC-MixRisk, EuroMix, EUToxRisk, HBM4EU and SOLUTIONS have started an exchange between the consortia, European Commission Services and EU Agencies, in order to identify where new methodologies have become available and where remaining gaps need to be further addressed. This paper maps how the different projects contribute to the data needs and assessment methodologies and identifies remaining challenges to be further addressed for the assessment of chemical mixtures.
JRC Directorate:Health, Consumers and Reference Materials

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