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dc.contributor.authorSACHANA MAGDAen_GB
dc.contributor.authorPRICE ANNAen_GB
dc.contributor.authorCROFTON KEVIN Men_GB
dc.contributor.authorBENNEKOU SUSANNEen_GB
dc.contributor.authorSHAFER TIMOTHYen_GB
dc.contributor.authorBEHL MAMTAen_GB
dc.contributor.authorTERRON ANDREAen_GB
dc.identifier.citationTOXICOLOGICAL SCIENCES vol. 167 no. 1en_GB
dc.identifier.issn1096-6080 (online)en_GB
dc.description.abstractThe Organisation for Economic Co-operation and Development (OECD) coordinates international efforts to enhance developmental neurotoxicity (DNT) testing. In most regulatory sectors, including the ones dealing with pesticides and industrial chemicals registration, historical use of the in vivo DNT test guideline has been limited. Current challenges include a lack of DNT data for a number of chemicals, lack of mechanistic information, and difficulty in interpreting results. A series of workshops in the last decade has paved the way for a consensus among stakeholders that there is need for a DNT testing battery that relies on in vitro methods and is complemented by alternative species assays. Preferably, a battery of in vitro and alternative assays should be anchored towards mechanistic relevance for applying an integrated approach for testing and assessment (IATA) framework. Specific activities have been initiated to facilitate this OECD project: the collation of available DNT in vitro methods and their scoring for readiness; the selection of these methods to form a DNT testing battery; the generation of a reference set of chemicals that will be tested using the battery; the case studies exemplifying how DNT in vitro data can be interpreted; and the development of an OECD guidance document. This manuscript highlights these international efforts and activities.en_GB
dc.description.sponsorshipJRC.F.3-Chemicals Safety and Alternative Methodsen_GB
dc.publisherOXFORD UNIV PRESSen_GB
dc.titleInternational regulatory and scientific effort for improved developmental neurotoxicity testingen_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1093/toxsci/kfy211 (online)en_GB
JRC Directorate:Health, Consumers and Reference Materials

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