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|Title:||Creation of a Curated Aquatic Toxicology Database: EnviroTox|
|Authors:||CONNORS KRISTIN; BEASLEY AMY; BARRON MACE; BELANGER SCOTT; BONNELL MARK; BRILL JESSICA; DEZWART DICK; KIENZLER AUDE; KRAILLER JESSE; OTTER RYAN; PHILLIPS JOSHUA; EMBRY MICHELLE|
|Citation:||ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY vol. 38 no. 5 p. 1062-1073|
|Type:||Articles in periodicals and books|
|Abstract:||Flexible, rapid, and predictive approaches that do not require the use of large numbers of vertebrate test animals are essential, as the chemical universe remains largely untested. Development of robust new approach methodologies (NAMs) and non-testing approaches requires availability of existing information via curated, integrated datasets. The ecological threshold of toxicological concern (eco-TTC) represents one such NAM approach that can identify a conservative, de minimis toxicity value for chemicals with little or no information available. A large, diverse dataset was developed from a range of sources, with harmonization and characterization steps to ensure that the information could be effectively organized and mined. The resulting EnviroTox database (www.envirotoxdatabase.org) contains 91,217 aquatic toxicity records representing 1,563 species, and 4,016 unique chemical CAS. Chemical-specific information is also linked to each record and includes physical chemical information, chemical descriptors, and mode of action classifications. Toxicity data is associated with the physical chemistry data, mode of action classifications, and curated taxonomic information for the organisms tested. The EnviroTox platform also includes three analysis tools: a predicted no effect concentration (PNEC) calculator, and eco-TTC distribution tool, and a chemical toxicity distribution (CTD) tool. Although the EnviroTox database and tools were originally developed to support eco-TTC analysis and development, it has broader applicability to the field of ecological risk assessment.|
|JRC Directorate:||Health, Consumers and Reference Materials|
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