Title: Resistance against PSMA-targeting alpha-radiation therapy coincides with mutations in DNA-repair associated genes
Authors: KRATOCHWIL CLEMENSHEUSSEL C.P.BRUCHERTSEIFER FRANKHABERKORN UWEMORGENSTERN ALFREDSTENZINGER ADUENSING SGIESEL FREDERIK
Citation: NUKLEARMEDIZIN-NUCLEAR MEDICINE vol. 58 no. 2 p. 145-146
Publisher: SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN
Publication Year: 2019
JRC N°: JRC113787
ISSN: 0029-5566 (online)
URI: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-1683592
http://publications.jrc.ec.europa.eu/repository/handle/JRC113787
DOI: 10.1055/s-0039-1683592
Type: Articles in periodicals and books
Abstract: PSMA-targeting alpha-radiation therapy (PSMA-TAT) is currently one of the most promising developments in the field of metastatic castration-resistant prostate cancer. However, there is a subgroup of patients with poor response, despite high expression of PSMA in their tumors. Aim of this work was to characterize a selection of highly radiation-resistant lesions, non-responding to PSMA-TAT by targeted next-generation sequencing (tNGS).
JRC Directorate:Nuclear Safety and Security

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