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|Title:||Resistance against PSMA-targeting alpha-radiation therapy coincides with mutations in DNA-repair associated genes|
|Authors:||KRATOCHWIL CLEMENS; HEUSSEL C.P.; BRUCHERTSEIFER FRANK; HABERKORN UWE; MORGENSTERN ALFRED; STENZINGER A; DUENSING S; GIESEL FREDERIK|
|Citation:||NUKLEARMEDIZIN-NUCLEAR MEDICINE vol. 58 no. 2 p. 145-146|
|Publisher:||SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN|
|Type:||Articles in periodicals and books|
|Abstract:||PSMA-targeting alpha-radiation therapy (PSMA-TAT) is currently one of the most promising developments in the field of metastatic castration-resistant prostate cancer. However, there is a subgroup of patients with poor response, despite high expression of PSMA in their tumors. Aim of this work was to characterize a selection of highly radiation-resistant lesions, non-responding to PSMA-TAT by targeted next-generation sequencing (tNGS).|
|JRC Directorate:||Nuclear Safety and Security|
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