Resistance against PSMA-targeting alpha-radiation therapy coincides with mutations in DNA-repair associated genes
PSMA-targeting alpha-radiation therapy (PSMA-TAT) is currently one of the most promising developments in the field of metastatic castration-resistant prostate cancer. However, there is a subgroup of patients with poor response, despite high expression of PSMA in their tumors. Aim of this work was to characterize a selection of highly radiation-resistant lesions, non-responding to PSMA-TAT by targeted next-generation sequencing (tNGS).
KRATOCHWIL Clemens;
HEUSSEL C.P.;
BRUCHERTSEIFER Frank;
HABERKORN Uwe;
MORGENSTERN Alfred;
STENZINGER A;
DUENSING S;
GIESEL Frederik;
2019-04-11
SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN
JRC113787
0029-5566 (online),
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-1683592,
https://publications.jrc.ec.europa.eu/repository/handle/JRC113787,
10.1055/s-0039-1683592 (online),
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