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dc.contributor.authorDESPREZ BERTRANDen_GB
dc.contributor.authorBIRK BARBARAen_GB
dc.contributor.authorBLAAUBOER BAS J.en_GB
dc.contributor.authorBOOBIS ALAN R.en_GB
dc.contributor.authorCARMICHAEL PAULen_GB
dc.contributor.authorCRONIN MARKen_GB
dc.contributor.authorCURRIE RICHARDen_GB
dc.contributor.authorDASTON GEORGEen_GB
dc.contributor.authorHUBESCH BRUNOen_GB
dc.contributor.authorJENNINGS PAULen_GB
dc.contributor.authorKLARIC MARTINAen_GB
dc.contributor.authorKROESE DINANTen_GB
dc.contributor.authorMAHONY CATHERINEen_GB
dc.contributor.authorOUÉDRAOGO GLADYSen_GB
dc.contributor.authorPIERSMA ALDERTen_GB
dc.contributor.authorRICHARZ ANDREAen_GB
dc.contributor.authorSCHWARZ MICHAELen_GB
dc.contributor.authorVAN BENTHEM JANen_GB
dc.contributor.authorVAN DE WATER BOBen_GB
dc.contributor.authorVINKEN MATHIEUen_GB
dc.identifier.citationTOXICOLOGY IN VITRO vol. 59 p. 44-50en_GB
dc.identifier.issn0887-2333 (online)en_GB
dc.description.abstractRepeated dose toxicity evaluation aims at assessing the occurrence of adverse effects following chronic or repeated exposure to chemicals. Non-animal approaches have gained importance in the last decades because of ethical considerations as well as due to scientific reasons calling for more human-based strategies. A critical aspect of this challenge is linked to the capacity to cover a comprehensive set of interdependent mechanisms of action, link them to adverse effects and interpret their probability to be triggered in the light of the exposure at the (sub)cellular level. Inherent to its structured nature, an ontology addressing repeated dose toxicity could be a scientific and transparent way to achieve this goal. Additionally, repeated dose toxicity evaluation through the use of a harmonized ontology should be performed in a reproducible and consistent manner, while mimicking as accurately as possible human physiology and adaptivity. In this paper, the outcome of a series of workshops organized by Cosmetics Europe on this topic is reported. As such, this manuscript shows how experts set critical elements and ways of establishing a mode-of-action ontology model as a support to risk assessors aiming to perform animal-free safety evaluation of chemicals based on repeated dose toxicity data.en_GB
dc.description.sponsorshipJRC.F.3-Chemicals Safety and Alternative Methodsen_GB
dc.titleA mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicityen_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1016/j.tiv.2019.04.005 (online)en_GB
JRC Directorate:Health, Consumers and Reference Materials

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