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dc.contributor.authorGEISS OTMARen_GB
dc.contributor.authorBIANCHI IVANAen_GB
dc.contributor.authorSENALDI CHIARAen_GB
dc.contributor.authorBARRERO JOSEFAen_GB
dc.date.accessioned2019-09-14T00:40:12Z-
dc.date.available2019-09-13en_GB
dc.date.available2019-09-14T00:40:12Z-
dc.date.created2019-08-26en_GB
dc.date.issued2019en_GB
dc.date.submitted2019-03-01en_GB
dc.identifier.citationANALYTICAL AND BIOANALYTICAL CHEMISTRY vol. 411 no. 22 p. 5817-5831en_GB
dc.identifier.issn1618-2642 (online)en_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC116007-
dc.description.abstractSynthetic amorphous silica is widely used in food processing as a food additive (E551) due to its properties as a flavour carrier and anti-caking agent. The direct measurement of E551 suspended or embedded in complex matrices is difficult without prior removal of the matrix components. The isolation of nanoparticles from the matrix is hence the first step towards their comprehensive characterization. Due to its complexity, matrix removal is frequently not trivial and may cause modification of the number-size distribution of the silica particles. The isolation of engineered silica nanoparticles by removal of the matrix with microwave-assisted acidic digestion is demonstrated methodologically using monodisperse and polydisperse (E551) particles spiked into ultrapure water and tomato sauce. For the characterization of the isolated nanoparticles, asymmetric field flow fractionation (AF4) coupled to multi-angle laser light scattering (MALS) and inductively coupled plasma mass spectrometry (ICP-MS) were chosen. The combination of ICP-MS and ultracentrifugation allowed for the rapid and reliable measurement of the dissolved fraction of SiO2. The results show that microwave-assisted acidic digestion partially dissolves silica nanoparticles. Moreover, the digestion conditions, in particular the low pH-value, lead to strong agglomeration of the particles. A complete deagglomeration is not achieved, even when exposing the suspension to elevated sonication doses. The consequence of these two findings is a number-size distribution of particles after acidic digestion that is different from the original distribution before digestion. This result may have an impact on the evaluation of whether the material is a nanomaterial according to the recommended definition of the European Commission.en_GB
dc.description.sponsorshipJRC.F.2-Consumer Products Safetyen_GB
dc.format.mediumOnlineen_GB
dc.languageENGen_GB
dc.publisherSPRINGER HEIDELBERGen_GB
dc.relation.ispartofseriesJRC116007en_GB
dc.titleChallenges in isolating silica particles from organic food matrices with microwave-assisted acidic digestionen_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1007/s00216-019-01964-2 (online)en_GB
JRC Directorate:Health, Consumers and Reference Materials

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