Methods for the SI-traceable value assignment of the purity of organic compounds (IUPAC Technical Report)
Metrological traceability to the SI of the result of an analysis for an organic compound is achieved through a calibration hierarchy anchored in a primary calibrator of the compound, the mass fraction content of which is established in a manner traceable within a stated uncertainty to the SI. The source material may be a pure substance Certified Reference Material (CRM) or a laboratory may choose to value assign a pure material with valid methods. The report describes the approach, performance and applicability of the principal methods used to determine organic purity – mass balance, quantitative NMR, thermal methods and other direct assay techniques. A statistical section reviews best practice for combination of data, value assignment as the upper limit values corresponding to 100% purity are reached and how to report and propagate the standard uncertainty associated with the assigned values.
WESTWOOD Steven;
LIPPA Katrice;
SHIMUZU Yoshitaka;
LALERLE Beatrice;
SAITO Takeshi;
DUEWER David L.;
DAI Xinhua;
DAVIES Stephen;
RICCI Marina;
BALDAN Annarita;
LANG Brian;
SARGE Stefan;
WANG Haifeng;
PRATT Ken;
JOSEPHS Ralf;
MARIASSY Mikael;
PFIEFFER Dietmar;
WARREN John;
BREMSER Wolfram;
ELLISON Steve;
TOMAN Blaza;
NELSON Michael;
HUANG Ting;
FAJGELJ Ales;
GOREN Ahmet Ceyhan;
MACKAY Lindsey;
WIELGOSZ Robert;
2023-03-13
WALTER DE GRUYTER GMBH
JRC116133
0033-4545 (online),
https://www.degruyter.com/document/doi/10.1515/pac-2020-0804/html,
https://publications.jrc.ec.europa.eu/repository/handle/JRC116133,
10.1515/pac-2020-0804 (online),
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