Title: Therapeutic Efficacy of 225Ac-containing Polymersomes
Authors: DE KRUIJFF R. M.RAAVE RKIP AMOLKENBOER- KUENEN JANNIKEMORGENSTERN ALFREDBRUCHERTSEIFER FRANKHESKAMP SANDRADENKOVA A.G.
Citation: JOURNAL OF MEDICAL IMAGING AND RADIATION SCIENCES vol. 50 no. 1 p. S7
Publisher: ELSEVIER BV
Publication Year: 2019
JRC N°: JRC116461
ISSN: 1939-8654 (online)
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC116461
DOI: 10.1016/j.jmir.2019.03.022
Type: Articles in periodicals and books
Abstract: Cancer, still presenting one of the major challenges in modern healthcare, leads to more than 8.8 million deaths annually. While the main treatment options include surgery, chemotherapy, and radiotherapy, increasing attention is given to brachytherapy in e.g. the treatment of prostate cancer. Advantages of brachytherapy, as compared to radical prostatectomy and external beam radiation therapy, lie in the much higher radiation doses which can be given to the tumour tissue whilst spearing healthy tissue. Whereas in classic brachytherapy careful placement of the seeds is still essential for optimal irradiation of the tumour, recently a movement towards the use of micro and nano particles for intratumoural administration has begun. These particles are able to distribute themselves to and within the tumour tissue, and can be labelled with either beta or alpha emitters. We have shown in the past that polymersomes are ideal candidates to be used in alpha therapy, as they are able to retain the recoiling daughter nuclides of 225Ac to a large extent, thus limiting the renal toxicity caused by recoiling daughters.
JRC Directorate:Nuclear Safety and Security

Files in This Item:
There are no files associated with this item.


Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.