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dc.contributor.authorRIVETTI CLAUDIAen_GB
dc.contributor.authorALLEN TIMOTHYen_GB
dc.contributor.authorBROWN JAMESen_GB
dc.contributor.authorBUTTLER EMMAen_GB
dc.contributor.authorCARMICHAEL PAULen_GB
dc.contributor.authorCOLBOURNE JOHNen_GB
dc.contributor.authorDENT MATHEWen_GB
dc.contributor.authorFALCIANI FRANCESCOen_GB
dc.contributor.authorGUNNARSON LINAen_GB
dc.contributor.authorGUTSELL STEVEen_GB
dc.contributor.authorHARRIL JOSHUAen_GB
dc.contributor.authorHODGES GEOFFen_GB
dc.contributor.authorJENNINGS PAULen_GB
dc.contributor.authorJUDSON RICHARDen_GB
dc.contributor.authorKIENZLER AUDEen_GB
dc.contributor.authorMARGIOTTA-CASALUCI LUIGIen_GB
dc.contributor.authorMULLER IRISen_GB
dc.contributor.authorOWEN STEWART Fen_GB
dc.contributor.authorRENDAL CECILIEen_GB
dc.contributor.authorRUSSEL PAULen_GB
dc.contributor.authorSCOTT SHARONen_GB
dc.contributor.authorSEWELL FIONAen_GB
dc.contributor.authorSHAH IMRANen_GB
dc.contributor.authorSORREL IANen_GB
dc.contributor.authorVIANT MARKen_GB
dc.contributor.authorWESTMORELAND CARLen_GB
dc.contributor.authorWHITE A.en_GB
dc.contributor.authorCAMPOS BRUNOen_GB
dc.identifier.citationTOXICOLOGY IN VITRO vol. 62 p. 104692en_GB
dc.identifier.issn0887-2333 (online)en_GB
dc.description.abstractThere is a growing recognition that application of mechanistic approaches to understand cross-species shared molecular targets and pathway conservation in the context of hazard characterization, provide significant opportunities in risk assessment (RA) for both human health and environmental safety. Specifically, it has been recognized that a more comprehensive and reliable understanding of similarities and differences in biological pathways across a variety of species will better enable cross-species extrapolation of potential adverse toxicological effects. Ultimately, this would also advance the generation and use of mechanistic data for both human health and environmental RA. A workshop brought together representatives from industry, academia and government to discuss how to improve the use of existing data, and to generate new NAMs data to derive better mechanistic understanding between humans and environmentally-relevant species, ultimately resulting in holistic chemical safety decisions. Thanks to a thorough dialogue among all participants, key challenges, current gaps and research needs were identified, and potential solutions proposed. This discussion highlighted the common objective to progress toward more predictive, mechanistically based, data-driven and animal-free chemical safety assessments. Overall, the participants recognized that there is no single approach which would provide all the answers for bridging the gap between mechanism-based human health and environmental RA, but acknowledged we now have the incentive, tools and data availability to address this concept, maximizing the potential for improvements in both human health and environmental RA.en_GB
dc.description.sponsorshipJRC.F.3-Chemicals Safety and Alternative Methodsen_GB
dc.titleVision of a near future: bridging the Human Health – Environment divide. Toward an integrated strategy to understand mechanisms across species for chemical safety assessmenten_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1016/j.tiv.2019.104692 (online)en_GB
JRC Directorate:Health, Consumers and Reference Materials

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