Title: Targeted alpha therapy with bismuth-213 and actinium-225: Meeting future demand
Authors: BRUCHERTSEIFER FRANKKELLERBAUER ALBANMALMBECK RIKARDMORGENSTERN ALFRED
Citation: JOURNAL OF LABELLED COMPOUNDS vol. 62 no. 11 p. 794-802
Publisher: JOHN WILEY & SONS INC.
Publication Year: 2019
JRC N°: JRC117532
ISSN: 0022-2135 (online)
URI: https://publications.jrc.ec.europa.eu/repository/handle/JRC117532
DOI: 10.1002/jlcr.3792
Type: Articles in periodicals and books
Abstract: Targeted alpha therapy (TAT) is a promising approach for the treatment of cancer. The use of alpha emitters for cancer therapy has two distinct advantages over conventional therapies. The short range of alpha radiation in human tissue (less than 0.1 mm), corresponding to only a few cell diameters, allows selective killing of targeted cancer cells while sparing surrounding healthy tissue. At the same time, the high energy (several MeV) of alpha radiation and its associated high linear energy transfer leads to highly effective cell kill. Consequently, alpha radiation can destroy cells which otherwise exhibit resistance to treatment with beta or gamma irradiation or chemotherapeutic drugs, and can thus offer a therapeutic option for tumors resistant to conventional therapies. Recent results demonstrating the remarkable therapeutic efficacy of alpha emitters to treat various cancers have underlined the clinical potential of TAT. This paper describes the recent clinical experience with 213Bi and 225Ac. In view of the enormous benefit of targeted cancer treatment with alpha emitters, their production will have to be considerably increased beyond current supply capabilities. Alternative production methods based on the irradiation of uranium, thorium, or radium targets at reactors or accelerator facilities have the potential to meet future demand.
JRC Directorate:Nuclear Safety and Security

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