Title: A Framework for Grouping and Read-Across of Nanomaterials- Supporting Innovation and Risk Assessment
Authors: STONE VICKIGOTTARDO STEFANIABLEEKER ERICBRAAKHUIS HEDWIGDEKKERS SUSANFERNANDES TERESA F.HAASE ANDREAHUNT NEILHRISTOZOV DANAILJANTUNEN ANNA PAULAJELIAZKOVA NINAJOHNSTON HELINORLAMON LARAMURPHY FIONARASMUSSEN KIRSTENRAUSCHER HUBERTCLAUS SVENDSENSANCHEZ JIMENEZ ARACELISPURGEON DAVIDVÁZQUEZ-CAMPOS SOCORROWOHLLEBEN WENDELOOMEN AGNES
Citation: NANO TODAY vol. 35 p. 100941
Publisher: ELSEVIER SCI LTD
Publication Year: 2020
JRC N°: JRC117973
ISSN: 1748-0132 (online)
URI: https://publications.jrc.ec.europa.eu/repository/handle/JRC117973
DOI: 10.1016/j.nantod.2020.100941
Type: Articles in periodicals and books
Abstract: According to legislation grouping can streamline data generation for the risk assessment of substances. The GRACIOUS Framework aims to support the grouping to nanomaterials or nanoforms (NFs), in a regulatory context and to support innovation. This includes using grouping to support read-across from (a) source(s), for which data and information exist, to a similar target NF where information is lacking. The Framework provides an initial set of hypotheses for the grouping of NFs which take into account the identity and use(s) of the NFs, as well as the purpose of grouping. Initial collection of basic information allows selection of an appropriate pre-defined grouping hypothesis and a tailored Integrated Approach to Testing and Assessment (IATA), designed to generate new evidence to support acceptance or rejection of the hypothesis. Users needing to develop their own case-specific hypothesis (and IATA) are also supported by the Framework. In addition, the IATA guides acquisition of the information needed to support read-across. This approach gathers information to render risk assessment more efficient, affordable, as well as reducing the use of test animals.
JRC Directorate:Health, Consumers and Reference Materials

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