Global Harmonization of Vaccine Testing Requirements: Making Elimination of the ATT and TABST a Concrete Global Achievement

This one-day symposium organized by Humane Society International (HSI) brought together 18 international experts from Argentina, Brazil, China, Europe, India, Russia, South Africa and the United States to discuss the elimination of the abnormal toxicity test (ATT) from the testing requirements for human vaccines as well as the target animal batch safety test (TABST) and the laboratory animal batch safety test (LABST) for veterinary vaccines. Participants reported on country-specific regulatory requirements and, where present, the perspectives on waiver and elimination of those tests. In addition, the attendees, with HSI in the role of facilitator, moved to define the barriers to the complete elimination or waiving of these tests. This report expounds the outcomes of the symposium, and introduces a proposed roadmap – populated with country specific activities – for the elimination of these tests.

VIVANI Laura;  HALDER Maria Elisabeth;  GRUBER Marion;  BRUCKNER Lukas;  CUSSLER Klaus;  SANYAL Gautam;  SRINIVAS Geetha;  GOEL Sunil;  KAASHOEK Marianne;  LITTHAUER Derek;  LOPES DA SILVA Arthur Leonardo;  SAKANYAN Elena;  APREA Patricia;  JIN Hongtao;  VANDEPUTTE Joris;  SEIDLE Troy;  YAKUNIN Dimitriy; 

2020-03-17

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD

JRC118049

1045-1056 (online),   

https://publications.jrc.ec.europa.eu/repository/handle/JRC118049,   

10.1016/j.biologicals.2019.10.007 (online),