Title: 21st Century Approaches for Evaluating Exposures, Biological Activity, and Risks of Complex Substances: Workshop highlights
Authors: . SAUER URSULA GBARTER ROBERT A.BECKER RICHARDBENFENATI EMILIOBERGGREN ELISABETHUBESCH BRUNOHOLLNAGEL HELIINAKAWA KUNIFUMIKEENE ATHENAMAYER PHILIPPPLOTZKE KATHLEENSKOGLUND ROBERTALBERT OCÉANE
Citation: REGULATORY TOXICOLOGY AND PHARMACOLOGY vol. 111 p. 104583
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Publication Year: 2020
JRC N°: JRC118430
ISSN: 0273-2300 (online)
URI: https://www.sciencedirect.com/science/article/pii/S027323002030009X?via%3Dihub
https://publications.jrc.ec.europa.eu/repository/handle/JRC118430
DOI: 10.1016/j.yrtph.2020.104583
Type: Articles in periodicals and books
Abstract: The June 2019 workshop 21st Century Approaches for Evaluating Exposures, Biological Activity, and Risks of Complex Substances, co-organised by the International Council of Chemical Association's Long-Range Research Initiative and the European Commission's Joint Research Centre, is summarised. Focus was the need for improved approaches to evaluate the safety of complex substances. Approximately 10% and 20% of substances registered under the EU chemicals legislation are ‘multi-constituent substances’ and ‘substances of unknown or variable compositions, complex reaction products and biological substances’ (UVCBs), respectively, and UVCBs comprise approximately 25% of the U.S. Toxic Substances Control Act Inventory. Workshop participants were asked to consider how the full promise of new approach methodologies (NAMs) could be brought to bear to evaluate complex substances. Sessions focused on using NAMs for screening, biological profiling, and in complex risk evaluations; improving read-across approaches employing new data streams; and methods to evaluate exposure and dosimetry. The workshop concluded with facilitated discussions to explore actionable steps forward. Given the diversity of complex substances, no single ‘correct’ approach was seen as workable. The path forward should focus on ‘learning by doing’ by developing and openly sharing NAM-based fit-for-purpose case examples for evaluating biological activity, exposures and risks of complex substances.
JRC Directorate:Health, Consumers and Reference Materials

Files in This Item:
There are no files associated with this item.


Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.