Title: EURL ECVAM Genotoxicity and Carcinogenicity Database of Substances Eliciting Negative Results in the Ames Test: Construction of the Database
Authors: MADIA FEDERICA ANNA CARLAKIRKLAND DAVIDMORITA TAKESHIWHITE PAULASTURIOL BOFILL DAVIDCORVI RAFFAELLA
Citation: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS vol. 854-855 no. 503199 p. 1-11
Publisher: ELSEVIER SCIENCE BV
Publication Year: 2020
JRC N°: JRC119302
ISSN: 1383-5718 (online)
URI: https://www.sciencedirect.com/journal/mutation-research-genetic-toxicology-and-environmental-mutagenesis/articles-in-press
https://publications.jrc.ec.europa.eu/repository/handle/JRC119302
DOI: 10.1016/j.mrgentox.2020.503199
Type: Articles in periodicals and books
Abstract: The bacterial reverse mutation test (Ames test) is the most commonly used genotoxicity test; it is a primary component of the chemical safety assessment data required by regulatory agencies worldwide. Within the current accepted in vitro genotoxicity test battery, it is considered capable of revealing DNA reactivity, and identifying substances that can produce gene mutations via different mechanisms. Evaluating the predictivity of the Ames test for in vivo genotoxicity and carcinogenicity, when considered alone or in association with mammalian cell assays for chromosome damage and/or gene mutations, is a laudable and important endeavour. The previously published consolidated EURL ECVAM Genotoxicity and Carcinogenicity Database, which includes substances that elicited a positive response in the Ames test, constitutes a collection of data that serves as a reference for a number of regulatory activities in the area of genotoxicity testing. Consequently, we considered it important to expand the database to include substances that fail to elicit a positive response in the Ames test, i.e., Ames negative substances. Here, we describe a curated collection of 211 Ames negative substances, with a summary of complementary data available for other genotoxicity endpoints in vitro and in vivo, plus available carcinogenicity data. A descriptive analysis of the data is presented. This includes a representation of the chemical space formed by the Ames negative database with respect to other substances (e.g. REACH registered substances, approved drugs, pesticides, etc.) and a description of the organic functional groups found in the database. We also provide some suggestions on further analyses that could be made.
JRC Directorate:Health, Consumers and Reference Materials

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