Identification of 1-Butyl-Lysergic Acid Diethylamide (1B-LSD) in Seized Blotter Paper Using an Integrated Workflow of Analytical Techniques and Chemo-Informatics

The rapid dispersion of new psychoactive substances (NPS) presents challenges 16 to customs services and analytical laboratories, which are involved in their detection and 17 characterization. When the seized material is limited in quantity or of a complex nature, or 18 when the target substance is present in very small amounts, the need to use advanced 19 analytical techniques, efficient workflows and chemo-informatics tools is essential for the 20 complete identification and elucidation of these substances. The current work describes the 21 application of such a workflow in the analysis of a single seized blotter paper, by the Swedish 22 customs, that led to the identification of a lysergic acid diethylamide (LSD) derivative, 23 1-butyl-lysergic acid diethylamide (1B-LSD). Such blotters paper generally contain amount 24 in the range of 30 - 100 ug. This substance, which is closely related to 1-propionyl-lysergic 25 acid diethylamide (1P-LSD), seems to have only recently reached the drugs street market. Its 26 identification was made possible by comprehensively combining gas chromatography with 27 mass spectrometry detection (GC-MS), liquid chromatography coupled with high-resolution 28 tandem MS (LC-HR-MS/MS), Orbitrap-MS and both 1D and 2D nuclear magnetic resonance 29 (NMR) spectroscopy. All the obtained data have been managed, assessed, processed and 30 evaluated using a chemo-informatics platform to produce the effective chemical and 31 structural identification of 1B-LSD in the seized material.

TSOCHATZIS Emmanouil;  ALBERTO LOPES João Filipe;  RENIERO Fabiano;  HOLLAND Margaret;  ABERG Jenny;  GUILLOU Claude; 

2021-02-08

MDPI

JRC119935

1420-3049 (online),   

https://www.mdpi.com/1420-3049/25/3/712,    https://publications.jrc.ec.europa.eu/repository/handle/JRC119935,   

10.3390/molecules25030712 (online),