Reversing cold tumor microenvironment with targeted alpha-therapy
Actual cancer therapies are facing numerous challenges towards tumor cell destruction : tumor microenvironment involves immunoregulatory cells and cytokines, which prevent anti-tumoral immune response. Therapeutic combination could be the key to turn these « cold » tumor microenvironment into « hot » ones : more vascularised and infiltrated with immune cells. To this end, this project focus on combining targeted alpha-therapy (TAT) and adoptive T-cells transfer (ACT).
PERRIN Justine;
CAPITAO Marisa;
GOUARD S.;
SAÏ-MAUREL C;
LOUVET Cedric;
LANCIEN M;
BRUCHERTSEIFER Frank;
MORGENSTERN Alfred;
CHEREL M.;
GASCHET J;
GUILLOUX Yannick;
2020-10-15
SPRINGER
JRC121369
1619-7070 (online),
https://publications.jrc.ec.europa.eu/repository/handle/JRC121369,
10.1007/s00259-020-04988-4 (online),
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