Systematic organization of COVID-19 data supported by the Adverse Outcome Pathway framework

Adverse Outcome Pathways (AOP) provide structured frameworks for systematic organization of research data and knowledge. The AOP framework follows a set of key principles that allow for broad application across diverse disciplines related to human health, including toxicology, pharmacology, virology and medical research. The COVID-19 pandemic engages a great number of scientists world-wide and data is increasing with exponential speed. Diligent data management strategies are employed but approaches for systematically organizing the data-derived information and knowledge are lacking. We believe AOPs can play an important role in improving interpretation and efficient application of scientific understanding of COVID-19. Here, we outline a newly initiated effort to streamline collaboration between scientists across the world towards development of AOPs for COVID-19, and describe the overarching aims of the effort, as well as the expected outcomes and research support that they will provide.

NYMARK P.;  SACHANA Magda;  BATISTA LEITE Sofia;  SUND Jukka;  KREBS Catharine;  SULLIVAN Kristie;  EDWARDS Stephen;  VIVIANI Laura;  WILLETT Catherine;  LANDESMANN Brigitte;  WITTWEHR Clemens; 

2021-05-21

FRONTIERS MEDIA SA

JRC122629

2296-2565 (online),   

https://www.frontiersin.org/articles/10.3389/fpubh.2021.638605/full,    https://publications.jrc.ec.europa.eu/repository/handle/JRC122629,   

10.3389/fpubh.2021.638605 (online),