Radiochemical separation of 224Ra from 232U and 228Th sources for 224Ra/212Pb/212Bi generator

The application of diagnostic and therapeutic radionuclides in nuclear medicine has grown significantly and has translated into the increased interest in radionuclide generators and their development. 224Ra and its shorterlived daughters, 212Pb and 212Bi, are very interesting radionuclides from Targeted Alpha Therapy point of view for treatment of small cancers or metastatic forms. The purpose of the present work was to develop a simple generator for rapid elution of carrier-free 224Ra from 232U or 228Th sources by radiochemical separation based on extraction chromatography with the utilization of a home-made material. The bis(2-ethylhexyl) hydrogen phosphate (HDEHP) extractant was immobilized on polytetrafluroethylene (PTFE) grains and its ability to selectively adsorb 232U and 228Th, with simultaneous high elution recovery of 224Ra, was checked over few years. The 224Ra was quantitatively eluted with small volume (3–5 mL) of 0.1 M HNO3 with low breakthrough (<0.005%) and was used for further milking of 212Bi and 212Pb from DOWEX 50WX12 by 0.75 M and 2.0 M HCl, respectively. The elaborated here methods allowed high recovery of 224Ra, 212Pb and 212Bi radionuclides and their application in radiolabeling of various biomolecules.

PRUSZYNSKI Marek;  WALCZAK Rafal;  RODAK Magdalena;  BRUCHERTSEIFER Frank;  MORGENSTERN Alfred;  BILEWICZ Aleksander; 

2021-03-17

PERGAMON-ELSEVIER SCIENCE LTD

JRC124229

0969-8043 (online),   

https://www.sciencedirect.com/science/article/pii/S0969804321000658?via%3Dihub,    https://publications.jrc.ec.europa.eu/repository/handle/JRC124229,   

10.1016/j.apradiso.2021.109655 (online),