Characterization of nanoparticles-based vaccines for COVID-19
Several vaccines against COVID-19 use nanoparticles to protect the antigen cargo (either proteins or nucleic acids), increase
the immunogenicity and ultimately the efficacy. The characterization of these nanomedicines is challenging due to their intrinsic
complexity and requires the use of multidisciplinary techniques and competencies. The accurate characterization of nanovaccines
can be conceptualized as a combination of physicochemical, immunological and toxicological assays. This will help to
address key challenges in the preclinical characterization, will guide the rapid development of safe and effective vaccines for
current and future health crises, and will streamline the regulatory process.
GUERRINI Giuditta;
MAGRI Davide;
GIORIA Sabrina;
MEDAGLINI Donata;
CALZOLAI Luigi;
2023-01-13
NATURE PUBLISHING GROUP
JRC124722
1748-3387 (online),
https://doi.org/10.1038/s41565-022-01129-w,
https://publications.jrc.ec.europa.eu/repository/handle/JRC124722,
10.1038/s41565-022-01129-w (online),
Additional supporting files
| File name | Description | File type | |
|---|
