Neurodegenerative Diseases
The JRC’s EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) launched a study to collect current and emerging non-animal models used in the field of neurodegenerative diseases. The overall aim is to provide an inventory and scientific evaluation of innovative (human-based) non-animal models and approaches currently in use for basic and applied research in the field of neurodegenerative diseases, more specifically Alzheimer’s and Parkinson’s disease.
More than 13,000 abstracts were screened to review and catalogue different alternative methods developed or used between 2013 and 2018. The resulting inventory includes 568 models, ranging from biochemical and computational approaches to different types of cell cultures and procedures using ex vivo human material. The inventory supports increased adoption and acceptance of alternative methods in neurodegenerative disease research and provides insights into emerging trends and promising areas for further development.
WITTERS Hilda;
VERSTRAELEN Sandra;
AERTS Liesbeth;
MICCOLI Beatrice;
DELAHANTY Aaron;
DURA Adelaide;
GRIBALDO Laura;
WHELAN Maurice;
European Commission: Joint Research Centre, WITTERS, H., VERSTRAELEN, S., AERTS, L., MICCOLI, B., DELAHANTY, A., DURA, A., GRIBALDO, L. and WHELAN, M., Advanced Non-animal Models in Biomedical Research, Publications Office of the European Union, Luxembourg, 2021, https://data.europa.eu/doi/10.2760/093006, JRC124723.
2021-04-27
Publications Office of the European Union
JRC124723
978-92-76-35944-9 (online),
978-92-76-35945-6 (print),
1831-9424 (online),
1018-5593 (print),
EUR 30334/2 EN,
OP KJ-NE-30334-EN-N (online),
OP KJ-NE-30334-EN-C (print),
https://publications.jrc.ec.europa.eu/repository/handle/JRC124723,
10.2760/386 (online),
10.2760/093006 (print),
