COVID-19 through Adverse Outcome Pathways: building networks to better understand the disease – Report of the 3rd CIAO AOP Design Workshop

On 28-29 April 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO Workshop. The CIAO project “Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework” aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological Key Events (KE) toward an adverse outcome, such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network, highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed, as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated integrating viral variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.

CLERBAUX Laure-Alix;  AMIGÓ Núria;  AMORIM Maria Joao;  PRICE Anna;  BATISTA LEITE Sofia;  BERONIUS Anna;  BEZEMER Gillina F.G.;  BOSTROEM Ann-Charlotte;  CARUSI Annamaria;  COECKE Sandra;  CONCHA Rachel;  DASKALOPOULOS Evangelos;  DEBERNARDI Francesca;  EDROSA Ezileayne;  EDWARDS Stephen;  FILIPOVSKA Julija;  GARCIA-REYERO Natalia;  GAVINS Felicity N.E.;  HALAPPANAVAR Sabina;  HARGREAVES Alan;  HOGBERG Helena T.;  HUYNH Mylène T.;  JACOBSON Daniel A.;  JOSEPHS-SPAULDING Jonathan;  KIM Young Jun;  KONG Hyun Joon;  KREBS Catharine;  LAM Ann;  LANDESMANN Brigitte;  LAYTON Adrienne Racanelli;  LEE Young Oh;  MACMILLAN Donna;  MANTOVANI Alberto;  MARGIOTTA-CASALUCI Luigi;  MARTENS Marvin;  MASEREEUW Rosalinde;  MAYASICH Sally A.;  MERLIN Liang Mei;  MORTENSEN Holly;  MUNOZ-PINEIRO Maria Amalia;  NYMARK P.;  OHAYON Elan;  OJASI Joshi Manoj;  PAINI Alicia;  PARISSIS Nikolaos;  PARVATAM Surat;  PISTOLLATO Francesca;  SACHANA Magdalini;  SØRLI Jorid Birkelund;  SULLIVAN Kristie;  SUND Jukka;  TANABE Shihori;  TSAIOUN Katya;  VINKEN Mathieu;  VIVIANI Laura;  WASPE Jennifer;  WILLETT Catherine;  WITTWEHR Clemens; 

2022-09-23

SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH

JRC125710

1868-596X (online),   

https://www.altex.org/index.php/altex/article/view/2396,    https://publications.jrc.ec.europa.eu/repository/handle/JRC125710,   

10.14573/altex.2112161 (online),