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|Title:||The EC/HO International Validation Study on Alternative Methods to the Draize Eye Irritation Test|
|Authors:||BALLS Michael; BOTHAM Philip a.; SPIELMANN Horst|
|Citation:||Toxicology in Vitroi vol. 9 no. 6 p. 871-929|
|Type:||Articles in periodicals and books|
|Abstract:||This is the final report of the Management Team for a European Commission/British Home Office (EC/HO) validation study on alternatives to the Draize eye irritation test. The principal goal of the study was to established whether one or more of nine non-animal tests could be used to replace the Draize test for all severely irritating materials (or those belonging to specific classes) or the animal test completely for chemicals with or without regard to chemical class. Sixty chemicals were indipendently selected, coded and supplie, then the data obtained in 37 laboratories were analysed indipendently. The results of comparisons between 27 alternative test index scores and the Modified Maximum Avarage Scores (MMASs) obtained in the Draize eye test were compared. Tables of results showing Pearson's product moment correlation coefficients and Spearman's rank coefficients for each laboratory are provided, and correlation matrices of alternative test index scopres among the different groups of laboratories are shown for each endpoint.|
|JRC Directorate:||Joint Research Centre Historical Collection|
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