Study of radioactive progeny recoils release from 225Ac labelled TiO2 nanoparticles

Targeted alpha therapy (TAT) plays an important role in palliative as well as curative treatment of patients with oncological diseases. Several radionuclides suitable for TAT are decaying by emission of an α-particle cascade, which can on one hand improve therapeutic outcome, but on the other hand also cause severe damage to non-target tissues. One strategy to at least partially reduce this progeny spread over the body is based on the use of nanoparticles (NPs). The aim of this work was to determine the fraction of recoiling atoms activity originating from 225Ac decay (221Fr, 213Bi) and study the progeny wash-out dependence over time and on the concentration of TiO2 NPs as a potential carrier of radionuclides for TAT.

SAKMAR Michal;  KOZEMPEL J.;  ONDRAK Lukas;  FIALOVA Katerina;  VLK M.;  MORGENSTERN Alfred;  BRUCHERTSEIFER Frank; 

2022-12-16

SPRINGER

JRC129439

1619-7070 (online),   

https://publications.jrc.ec.europa.eu/repository/handle/JRC129439,   

10.1007/s00259-022-05924-4 (online),