New Approach Methodologies (NAMs) are considered to include any in vitro, in silico or chemistry-based method, as well as the strategies to implement them, that may provide information that could inform chemical safety assessment. Current chemical legislation in the European Union is limited in its acceptance of the widespread use of NAMs. The European Partnership for Alternative Approaches to Animal Testing (EPAA) therefore convened a ‘Deep Dive Workshop’ to explore the use of NAMs in chemical safety assessment, the aim of which was to support regulatory decisions, whilst intending to protect human health. The workshop recognised that NAMs are currently used in many industrial sectors, with some considered as fit for regulatory purpose. Moreover, the workshop identified key discussion points that can be addressed to increase the use and regulatory acceptance of NAMs. These are based on the changes needed in frameworks for regulatory requirements and the essential needs in education, training and greater stakeholder engagement as well the gaps in the scientific basis of NAMs.

WESTMORELAND Carl;  BENDER Hans J;  DOE John E.;  JACOBS Miriam N;  KASS George;  MADIA Federica Anna Carla;  MAHONY Catherine;  MANOU Irene;  MAXWELL Gavin;  PRIETO PERAITA Maria Del Pilar;  ROGGEBAND Rob;  SOBANSKI Tomasz;  SCHÜTTE Katrin;  WORTH Andrew;  ZVONAR Zvonimir;  CRONIN Mark T.D.; 

2022-10-03

ACADEMIC PRESS INC ELSEVIER SCIENCE

JRC129762

0273-2300 (online),   

https://www.sciencedirect.com/science/article/pii/S0273230022001489,    https://publications.jrc.ec.europa.eu/repository/handle/JRC129762,   

10.1016/j.yrtph.2022.105261 (online),