Poor Translatability of Biomedical Research Using Animals — A Narrative Review
The failure rates for the translation of drugs from animal testing to human treatment remains at over 90%, where it has been for the past few decades. The majority of these failures are due to unexpected toxicity, that is safety issues revealed in human trials that were not apparent in animal tests, or lack of efficacy. However, use of more innovative tools, such as organ-chips, in the preclinical pipeline for drug testing have revealed that these tools are more able to predict unexpected safety events prior to clinical trials and can be applied for efficacy testing. Here we review several disease areas, considering how the use of animal models has failed to offer effective new treatments and how the more human-relevant methodologies might be applied to address this.
MARSHALL Lindsay;
BAILEY Jarrod;
CASSOTTA Manuela;
HERRMANN Kathrin;
PISTOLLATO Francesca;
2023-03-31
SAGE PUBLICATIONS LTD
JRC130396
0261-1929 (online),
https://journals.sagepub.com/doi/10.1177/02611929231157756,
https://publications.jrc.ec.europa.eu/repository/handle/JRC130396,
10.1177/02611929231157756 (online),
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