Validation of a battery of mechanistic methods relevant for the detection of chemicals that can disrupt the thyroid hormone system
Chemicals that can disrupt the thyroid hormone (TH) system can be found in everyday products and are considered to be endocrine disruptors (EDs).
For more than thirty years, the European Union (EU) has been working on EDs and has introduced legislative obligations aimed at phasing out EDs in water, industrial chemicals, plant protection products and biocides. This has so far led to the availability of in vitro test methods able to detect estrogen and androgen active chemicals. In 2014, the Organisation for Economic Co-operation and Development (OECD) published the New Scoping Document on in vitro and ex vivo assays for the identification of modulators of thyroid hormone signalling. In line with the European Commission’s policy on EDs and taking into account the information reported in the OECD scoping document, the European Commission’s European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) launched a validation study to validate a battery of thyroid-relevant mechanistic methods, which could be used as test methods within the OECD test guideline framework. In this validation study report, the organisation of the validation study, the mechanistic relevance of the assessed in vitro new approach methods (NAMs) and the achievements are described. The validation effort, complemented with efforts at international level, is aimed at contributing to mechanistic NAM data generation to support global regulatory processes to identify endocrine disrupting substances.
BERNASCONI Camilla;
LANGEZAAL Ingrid;
BARTNICKA Joanna;
ASTURIOL David;
BOWE Gerard;
COECKE Sandra;
KIENZLER Aude;
LISKA Roman;
MILCAMPS Anne;
MUNOZ-PINEIRO Maria Amalia;
PISTOLLATO Francesca;
WHELAN Maurice;
2023-04-26
Publications Office of the European Union
JRC132532
978-92-68-01257-4 (online),
1831-9424 (online),
EUR 31456 EN,
OP KJ-NA-31-456-EN-N (online),
https://publications.jrc.ec.europa.eu/repository/handle/JRC132532,
10.2760/862948 (online),
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