Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps.

Introduction. The AOP concept facilitates rapid hazard assessment for human health risks. AOPs are constantly evolving, their number is growing, and they are referenced in the AOP-Wiki database. Here, we present a study that aims at identifying well-defined biological areas and gaps within the AOP-Wiki for future research needs. It summarizes and maps biological knowledge and diseases represented by the already developed AOPs. Methods: Knowledge from the AOP-Wiki database were extracted and prepared for analysis using a multi-step procedure. An automatic mapping of the existing information on AOPs was performed using bioinformatics tools , allowing both the classification of AOPs and the development of AOPN. Results: AOPs related to diseases of the genitourinary system, neoplasms and developmental anomalies are the most frequently investigated on the AOP-Wiki. An evaluation of the three priority cases of the PARC project were used to highlight under- and over-represented adverse outcomes and to identify and prioritize gaps for further research. Discussion: These results contribute to a more comprehensive understanding of the adverse effects associated with the molecular events in AOPs, and aid in refining risk assessment for stressors and mitigation strategies. Moreover, the FAIRness of the AOPs appears to be an important consideration for further development.

JAYLET Thomas;  COUSTILLET Thibaut;  SMITH Nicola M.;  VIVIANI Barbara;  LINDEMAN Birgitte;  VERGAUWEN Lucia;  MYHRE Oddvar;  YARAR Nurettin;  GOSTNER Johanna M.;  MONFORT-LANZAS Pablo;  JORNOD Florence;  HOLBECH Henrik;  COUMOUL Xavier;  SARIGIANNIS Dimosthenis;  ANTCZAK Philipp;  BAL-PRICE Anna;  FRITSCHE Ellen;  KUCHOVSKA Eliska;  STRATIDAKIS Antonios K.;  BAROUKI Robert;  KIM Min Ji;  TABOUREAU Olivier;  WOJEWODZIC Marcin W.;  KNAPEN Dries;  AUDOUZE Karine; 

2024-03-21

Frontiers Media SA

JRC134946

2673-3080 (online),   

https://www.frontiersin.org/articles/10.3389/ftox.2024.1285768,    https://publications.jrc.ec.europa.eu/repository/handle/JRC134946,   

10.3389/ftox.2024.1285768 (online),