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Structure-Activity Relationship in the Induction of Chromosomal Aberrations and Spindle Disturbances in Chinese Hamster Epithelial Liver Cells by Regioisomeric Phenanthrene Quinones.
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Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their abilities to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q showed no significant effects in this regard. However, all four compounds enhanced the frequency of c-mitoses.
1996-07-31
JRC13508
https://publications.jrc.ec.europa.eu/repository/handle/JRC13508,   
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