Title: Structure-Activity Relationship in the Induction of Chromosomal Aberrations and Spindle Disturbances in Chinese Hamster Epithelial Liver Cells by Regioisomeric Phenanthrene Quinones.
Authors: TURCHI GinoSEIDEL AlbrechtPULITI AldamariaSBRANA Isabella
Citation: Cell Biology and Toxicology vol. 13 p. 155-165
Publication Year: 1997
JRC N°: JRC13508
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC13508
Type: Articles in periodicals and books
Abstract: Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their abilities to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q showed no significant effects in this regard. However, all four compounds enhanced the frequency of c-mitoses.
JRC Directorate:Joint Research Centre Historical Collection

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