Structure-Activity Relationship in the Induction of Chromosomal Aberrations and Spindle Disturbances in Chinese Hamster Epithelial Liver Cells by Regioisomeric Phenanthrene Quinones.
Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their abilities to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q showed no significant effects in this regard. However, all four compounds enhanced the frequency of c-mitoses.
TURCHI Gino;
SEIDEL Albrecht;
PULITI Aldamaria;
SBRANA Isabella;
1996-07-31
JRC13508
https://publications.jrc.ec.europa.eu/repository/handle/JRC13508,
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