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|Title:||Structure-Activity Relationship in the Induction of Chromosomal Aberrations and Spindle Disturbances in Chinese Hamster Epithelial Liver Cells by Regioisomeric Phenanthrene Quinones.|
|Authors:||TURCHI Gino; SEIDEL Albrecht; PULITI Aldamaria; SBRANA Isabella|
|Citation:||Cell Biology and Toxicology vol. 13 p. 155-165|
|Type:||Articles in periodicals and books|
|Abstract:||Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their abilities to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q showed no significant effects in this regard. However, all four compounds enhanced the frequency of c-mitoses.|
|JRC Directorate:||Joint Research Centre Historical Collection|
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