Basic Equations and Uncertainties in Isotope Dilution Mass Spectrometry for Traceability to SI of Values Obtained by that Primary Method.

A current interest in chemistry concerns traceability of analytical measurements to the Intern. System of Units (SI) and the estimation of their uncertainties in accordance with principles of metrology, that is measurement science. Primary methods of measurement achieve traceability to SI directly without intermediate reference standards or materials and without significant empirical correction factors. Isotope-dilution mass spectrometry is such a primary method with the potential of smallest presently achievable uncertainties for many analytical measurements. A simple explanation of the method is given in terms of current concepts, and general equations are derived. The required uncertainty estimation is emphasized in terms of these equations.

DE BIEVRE P.;  PEISER H. Steffen; 

1996-07-29

JRC13550

https://publications.jrc.ec.europa.eu/repository/handle/JRC13550,