Alternative Methods in Toxicological Research and Testing

Increasing public concern about the use of large numbers of animals in the safety evaluation of new chemicals and products has contributed, in part, to the development and evaluation of various non-animal methods in recent years. Several of these have been proposed as possible replacements for some of the animal procedures currently required in regulatory toxicity testing. In toxicological research, there has been a significant move away from whole animal studies, largely because of the application of cellular and molecular biology techniques. The development of appropriate in vitro test systems has enabled mechanistic studies to be undertaken, which cannot readily be carried out in living animals.

FENTEM Julia Helen;  BALLS Michael; 

1996-07-16

JRC13655