The certification of the mass concentrations of Cd, Cr, Hg, Ni, Pb and Tl in human blood. ERM®-DA634, ERM®-DA635 and ERM®-DA636
ERM-DA634, ERM-DA635 and ERM-DA636 are human blood reference materials certified for their mass concentrations of cadmium, chromium, mercury, nickel, lead and thallium (Cd, Cr, Hg, Ni, Pb and Tl). They were produced within the scope of ISO 17034 accreditation. .
Human blood was lysed, spiked with the six elements, dispensed into vials and lyophilised. The CRMs are available in sets of three glass vials, each containing equivalent to 1 mL freeze-dried blood.
Between-unit homogeneity was quantified and stability during transport and storage was assessed in accordance with ISO 33405:2024. The minimum sample size for one measurement is 150 mg for Hg and 250 mg for all other elements.
The material was characterised by an interlaboratory comparison of laboratories of demonstrated competence and adhering to ISO/IEC 17025:2017 or ISO 15189.
Uncertainties of the certified values were calculated in accordance with ISO 17034:2016 and include uncertainties related to possible inhomogeneity, instability and characterisation.
The materials are intended for the assessment of method performance, calibration of methods and quality control.
Before release of the CRMs, the certification project was subjected to peer-review involving both internal and external experts.
LINSINGER Thomas;
DEPREZ Liesbet;
AUCLAIR Guy;
2025-02-11
Publications Office of the European Union
JRC138775
978-92-68-21621-7 (online),
OP KJ-01-24-123-EN-N (online),
https://publications.jrc.ec.europa.eu/repository/handle/JRC138775,
10.2760/4057065 (online),
Additional supporting files
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