EURL ECVAM Status Report 2025
The 2025 EURL ECVAM Status Report presents a comprehensive overview of the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) recent advancements in the development, validation, and regulatory integration of non-animal methods, as well as progress made elsewhere. Anchored in the EU’s Three Rs framework of Replacement, Reduction, and Refinement, this report highlights innovative scientific breakthroughs including organ-on-chip technologies, artificial intelligence, and multi-omics approaches that collectively enhance the predictivity, efficiency, and ethical standards of safety assessment.
EURL ECVAM’s active participation in Horizon Europe initiatives, international standardisation efforts, and strategic partnerships reinforces its pivotal role in fostering a robust, innovation-driven ecosystem.
With the European Commission preparing to publish a roadmap for phasing out animal testing by 2026, this status report serves as a critical resource documenting scientific, regulatory, societal, and economic progress. It underlines EURL ECVAM’s commitment to evolving animal-free approaches that not only uphold EU ethical values but also promote sustainable growth, competitiveness, and public health outcomes in Europe and beyond.
ZUANG Valerie;
AHS LOPEZ Eva;
BACCARO Marta;
BARROSO João;
BERGGREN Elisabet;
BOPP Stephanie;
BRIDIO Sara;
CAPELOA Tania;
CARLETTI Alessandro;
CARPI Donatella;
CASATI Silvia;
CHINCHIO Eleonora;
CORVI Raffaella;
DECEUNINCK Pierre;
GASTALDELLO Annalisa;
KATSANOU Effrosyni;
LANGEZAAL Ingrid;
MALINOWSKA Julia;
MENNECOZZI Milena;
MILCAMPS Anne;
PIERGIOVANNI Monica;
PRIETO-PERAITA Pilar;
SAMPANI Stavroula;
SELFA ASPIROZ Lucia;
VALSESIA Debora;
WHELAN Maurice;
WITTWEHR Clemens;
WORTH Andrew;
ZUANG Valerie;
WORTH Andrew;
CASATI Silvia;
GASTALDELLO Annalisa;
2026-03-30
Publications Office of the European Union
JRC145459
978-92-68-37277-7 (online),
978-92-68-37278-4 (print),
1831-9424 (online),
1018-5593 (print),
EUR 40635,
EUR 40635 (print),
OP KJ-01-26-061-EN-N (online),
OP KJ-01-26-061-EN-C (print),
https://publications.jrc.ec.europa.eu/repository/handle/JRC145459,
10.2760/8549094 (online),
10.2760/0758050 (print),
