This report of an ECVAM workshop on pharmacokinetics in early drug research: a) reviews the current methodology for providing early pharmacokinetic and related information; b) defines current best practice and identifies those problem areas where scientific and technological advances could significantly improve the efficiency of drug discovery; and c) recommends further work which should be conducted in these high priority areas, which coul lead to a more effective use of animal studies while increasing the capacity for efficient optimisation of activity in vivo.
LEAHY David;
DUNCAN Ruth;
AHR Hans;
BAYLISS Martin K.;
DE BOER Bert G.;
DARVAS Ferenc;
FENTEM Julia Helen;
FRY Jeffrey R.;
HOPKINS Robert;
HOUSTON Brian J.;
KARLSSON Johan;
KEDDERIS Gregory L.;
PRATTEN Margaret;
SMITH Dennis A.;
STRAUGHAN Donald W.;
1997-03-17
JRC14551
https://publications.jrc.ec.europa.eu/repository/handle/JRC14551,
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