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Practical considerations regarding the imaging calibration factor for quantitative SPECT/CT of actinium-225
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Few studies refer to qualitative and quantitative imaging after administration of 225Ac. Different authors used different planar and SPECT acquisition protocols, including differently defined energy windows, number of projections, time per one projection and different methods for scatter correction (SC). Each of these factors can potentially have a major impact on the accuracy of quantitative imaging. Defining the parameters of the acquisition protocol for proper quantitative imaging appears to be a task of primary importance, if dosimetry and conducting 225Ac treatment under its control are the next steps.
2026-05-05
ELSEVIER INC.
JRC145584
1876-7982 (online),   
https://www.sciencedirect.com/science/article/pii/S1939865426000925,    https://publications.jrc.ec.europa.eu/repository/handle/JRC145584,   
10.1016/j.jmir.2026.102278 (online),   
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