Title: A Transgenic Mouse Model for the Detection of Cellular Stress Induced by Toxic Inorganic Compounds.
Authors: SACCO Maria graziaZECCA LuigiBAGNASCO LucaCHIESA GiuliaPAROLINI CinziaBROMLEY PeterMIRA CATO' EnricaRONCUCCI RomeoCLERICI Libero antonioVEZZONI Paolo
Citation: Nature Biotechnology vol. 15 p. 1392-1397
Publication Year: 1997
JRC N°: JRC15684
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC15684
Type: Articles in periodicals and books
Abstract: In the last few years plasmid-based transgenic mice which can be used for genotoxicitytesting have been devised, though no such models have yet been produced for the evaluation of toxic, non-genotoxic chemical compounds. We present here a novel approach to this problem based on transgenic mice.We engineered a mouse lineage with the human growth hormone(hGH) gene under the control of the human hsp-70 promoter, in which a plasma-detectable hGH response can be elicited by exposure to heat shock.
JRC Directorate:Joint Research Centre Historical Collection

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