The ECVAM International Validation Study on in Vitro Tests for Skin Corrosivity. 1. Selection and Distribution of the Test Chemicals.

An international validation study on IN VITRO tests for skin corrosivity was conducted during 1996 and 1997 under the auspices of the European Centre for the Validation of Alternative Methods (ECVAM). The main objectives of the study were to assess the performances of selected IN VITRO tests in discriminating between: (a) corrosives and non-corrosives, for selected groups of chemicals and/or for all chemicals (single chemical entities only); and (b) known R35 (UN packing group I) and R34 (UN packing groups II & III) chemicals. Each test was evaluated for reliability and relevance by using a test set of 60 coded chemicals. In this paper, the test chemicals used in the validation study are identified, and physico-chemical and IN VIVO data/classifications for them are given; they include organic acids (6C/5NC), organic bases (7C/3NC), neutral organics (9NC), phenols (2C/3NC), inorganic acids (6C/1NC), inorganic bases (2C/2NC), inorganic salts (1C/2NC), electrophiles (3C/5NC) and soaps/surfactants (3NC).

BARRATT Martin D.;  BRANTOM Paul G.;  FENTEM Julia Helen;  GERNER Ingrid;  WALKER Arthur P.;  WORTH Andrew; 

1998-09-16

JRC16649

https://publications.jrc.ec.europa.eu/repository/handle/JRC16649,