Production of Ac-225 from Th-229 for Targeted Alpha Therapy
This work describes a method for the separation and purification of Ac-225 from a Th-229 source. The procedure is based on the combination of ion exchange and
extraction chromatographic methods in nitric acid media and allows the preparation of carrier-free, clinical grade Ac-225 with an overall yield exceeding 95%. Quality
control of the product is performed using radiometric (r, ç spectrometry) and mass spectrometric methods. The Ac- 225 product can be loaded on a radionuclide generator
for the preparation of Bi-213 for preclinical and clinical studies of targeted r therapy of cancer and infectious diseases.
APOSTOLIDIS Christos;
MOLINET Roger;
MORGENSTERN Alfred;
2006-01-17
AMER CHEMICAL SOC
JRC30026
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