Title: Production of Ac-225 from Th-229 for Targeted Alpha Therapy
Citation: ANALYTICAL CHEMISTRY vol. 77 no. 19 p. 6288-6291
Publication Year: 2005
JRC N°: JRC30026
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC30026
Type: Articles in periodicals and books
Abstract: This work describes a method for the separation and purification of Ac-225 from a Th-229 source. The procedure is based on the combination of ion exchange and extraction chromatographic methods in nitric acid media and allows the preparation of carrier-free, clinical grade Ac-225 with an overall yield exceeding 95%. Quality control of the product is performed using radiometric (r, ç spectrometry) and mass spectrometric methods. The Ac- 225 product can be loaded on a radionuclide generator for the preparation of Bi-213 for preclinical and clinical studies of targeted r therapy of cancer and infectious diseases.
JRC Directorate:Nuclear Safety and Security

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