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dc.contributor.authorLESSIGIARSKA Iglikaen_GB
dc.contributor.authorWORTH ANDREWen_GB
dc.contributor.authorSOKULL-KLUETTGEN BIRGITen_GB
dc.contributor.authorJERAM Sonjaen_GB
dc.contributor.authorDEARDEN Johnen_GB
dc.contributor.authorNETZEVA TATIANAen_GB
dc.contributor.authorMARK Croninen_GB
dc.identifier.citationSar and Qsar in Environmental Research vol. 15 no. 5-6 p. 413-431en_GB
dc.description.abstractA large dataset containing values for fish, algae and Daphnia toxicity for more than 2000 chemical compounds and mixtures was investigated. The dataset was taken from the New Chemicals Data Base of the European Union [provided by the European Chemicals Bureau, Institute for Health and Consumer Protection (http://ecb.jrc.it)]. The data are collected from industry, according to requirements of the EU Council Directive 67/548/EEC as amended for the seventh time by the EU Council Directive 92/32/EEC. The toxicity of neural compounds, salts, metal complexes, as well as compound mixtures has been recorded. A baseline effect is demonstrated by compounds known to act by narcotic mechanisms of action i.e. a relationship is observed between the toxicity and the logarithm of the octanol-water partition coefficient (log P). Prediction of the toxicity of more reactive compounds requires the use of further descriptors.en_GB
dc.description.sponsorshipJRC.I.2-Validation of biomedical testing methodsen_GB
dc.publisherTaylor & Francis Groupen_GB
dc.titleQSAR investigation of a Large Data Set for Fish, Algae and Daphnia Toxicityen_GB
dc.typeArticles in periodicals and booksen_GB
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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