Fractionated Locoregional Low-Dose Radioimmunotherapy Improves Survival in a Mouse Model of Diffuse Type Gastric Cancer Using A 213BI-conjugated Monoclonal Antibody
Locoregional radioimmunotherapy of intraperitoneal tumor cell dissemination of diffuse type gastric cancer using the Alpha-emitter 213Bi displayed good therapeutic results after single application depending on the time interval between tumor cell inoculation and injection of the 213Bi-immunoconjugate. The aim of the present study was to compare single versus double intraperitoneal injection of a tumor specific antibody (d9MAb) conjugated with low activities of 213Bi in terms of therapeutic efficacy and toxicity.
BLOECHEL S.;
BECK R.;
SEIDL C.;
MORGENSTERN Alfred;
SCHWAIGER M.;
SENEKOWITSCH-SCHMIDTKE R.;
2005-12-20
AMER ASSOC CANCER RESEARCH
JRC30250
https://publications.jrc.ec.europa.eu/repository/handle/JRC30250,
10.1158/1078-0432,
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