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dc.contributor.authorCORVI RAFFAELLAen_GB
dc.contributor.authorAHR Hansen_GB
dc.contributor.authorALBERTINI Silvioen_GB
dc.contributor.authorBLAKEY Daviden_GB
dc.contributor.authorCLERICI Liberoen_GB
dc.contributor.authorCOECKE SANDRAen_GB
dc.contributor.authorDOUGLAS Georgeen_GB
dc.contributor.authorGRIBALDO LAURAen_GB
dc.contributor.authorGROTEN Johnen_GB
dc.contributor.authorHAASE Bernden_GB
dc.contributor.authorHAMERNIK Karenen_GB
dc.contributor.authorHARTUNG THOMASen_GB
dc.contributor.authorINOUE Tohruen_GB
dc.contributor.authorINDANS Ianen_GB
dc.contributor.authorMAURICI Danielaen_GB
dc.contributor.authorORPHANIDES Georgeen_GB
dc.contributor.authorREMBGES DIANAen_GB
dc.contributor.authorSANSONE Susannaen_GB
dc.contributor.authorSNAPE Jasonen_GB
dc.contributor.authorTODA Eisakuen_GB
dc.contributor.authorTONG Weidaen_GB
dc.contributor.authorVAN DELFT Joosten_GB
dc.contributor.authorWEIS Brendaen_GB
dc.contributor.authorSCHECHTMAN Leonarden_GB
dc.identifier.citationENVIRONMENTAL HEALTH PERSPECTIVES vol. 114 no. 2 p. 420-429en_GB
dc.description.abstractThis is the report of the first workshop on the Validation of Toxicogenomics-based Test Systems held in Ispra, Italy on 11-12 December 2003. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and organized jointly by ECVAM, the U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). The primary aim of the workshop was to discuss and define principles applicable to the validation of toxicogenomics platforms as well as validation of specific toxicological test methods that incorporate toxicogenomics technologies. The workshop was viewed as an opportunity for initiating a dialogue between technological experts, regulators, and the principal validation bodies, and for identifying those factors to which the validation process would be applicable. It was felt that to do so now, as the technology is evolving and associated challenges are identified, would serve as the basis for the future validation of the technology when it reached the appropriate stage. Due to the complexity of the issue, different aspects of the validation of toxicogenomics-based test methods were covered. The three focus areas included (a) biological validation of toxicogenomics-based test methods for regulatory decision-making, (b) technical and bioinformatics aspects related to validation, and (c) validation issues as they relate to regulatory acceptance and utilization of toxicogenomics-based test methods. This report summarizes the discussions and details the recommendations for future direction and priorities.en_GB
dc.description.sponsorshipJRC.I.2-Validation of biomedical testing methodsen_GB
dc.titleValidation of Toxicogenomics-Based Test Systems:ECVAM-ICCVAM/NICEATM Considerations for Regulatory Useen_GB
dc.typeArticles in periodicals and booksen_GB
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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