Exploratory Research Project Report - Application of the Threshold of Toxicological Concern (TTC) concept to Human Health Endpoints
The Threshold of Toxicological Concern (TTC) is a pragmatic risk assessment tool based on the principle of establishing a human exposure threshold value for all chemicals below which there is a very low probability of an appreciable risk to human health.
This report outlines the main concepts associated with the TTC, how it has evolved, how it is currently applied in risk assessment, and how it could complement future risk assessments in the context of REACH.
The paper begins by describing the traditional approach to risk assessment. It then outlines some of the non testing approaches such as (Q)SAR, read across, chemical categories and how these may fit into a risk assessment framework. Specific focus is made on TTC approaches and applications.
Finally, the report describes the outcome of an IHCP Exploratory Research project carried out during 2005 by the European Chemicals Bureau (Computational Toxicology Action) on the subject of the TTC.
TIER Grace;
2006-03-01
JRC31686
EUR 22128 EN,
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