Isotope Dilution with ICP-MS - Simplified Uncertainty Estimation using a Robust Procedure Based on a Higher Target Value of Uncertainty

The paper describes an a priori simuation process of the uncertainty that will be achieved using a validated procedure for an analyte in a matrix. for this, a valid model equation is built, where the different influence quantities are allowed to vary within a wide robust tolerance window. For these influence quantities an approximate measurement uncertainty contribution relative to the measured (i.e. quantity to be measured) is calculated and only those that significantly affect the measurement uncertainty (expanded k = 2, relative) at the target level are taken into account. A target value of uncertainty of 2% is used here as an example since it is deemed to be achievable by experienced laboratories that are not primarily concerned with measuring at a lower uncertainty level. The approach is demonstrated on the determination of nickel in low-alloy steel and copper in fresh water. However this basic approach using target uncertainty and wide tolerance windows is general and can easily be adapted for other applications.

MAGNUSSON Bertil;  TRESL Ivan;  HARALDSSON Conny; 

2006-01-24

ROYAL SOC CHEMISTRY

JRC32122

https://publications.jrc.ec.europa.eu/repository/handle/JRC32122,