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A new LC-MS/MS method has been developed for the multiresidue determination of 11 (fluoro)quinolone antibiotics (FQs), including acidic and aphoteric speices, around their maximum residue level (MRL) in pig kidney. The procedure involved a common sample preparation by solid-phase extraction on disposable extraction cartridges followed by a fast reversed-phase liquid chromatography-tandem mass spectrometry analysis. The method was validated according to the Commission Decision 2002/657/CE. The accuracy of the method was satisfactory with recoveries included in the interval 80-100%. The precision results showed mean repeatability and reproducibility coefficients of 7.4% and 11.8% respectively. Limits of quantification much lower than the MRLs could be obtained.
2006-03-28
ELSEVIER
JRC32898
https://publications.jrc.ec.europa.eu/repository/handle/JRC32898,   
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