Reference materials for thromboplastins are available from the World Health Organization (WHO) and the European Commission (EC). The long-term stability of the reference materials is an essential requirement and should be monitored. The relationship between two reference materials for rabbit thromboplastin, i.e. CRM149S (EC) and RBT/90 (WHO), has been monitored in the period 1996-2002. No significant trend with time was detected. In addition, the relatioship between CRM149S and the reference material for bovine thromboplastin (i.e. OBT/79) has been determined in 1994 and in 2005 in multicentre studies (n=11 and n=9, respectively). No significant changes were observed in the relationships between these reference materials when all results were included (5% significance level). When one center's outlying international sensitivity index (ISI) was excluded, a 4% difference in the mean ISI was significant at the 5% level.
LINSINGER Thomas;
VAN DEN BESSELAAR A.M.H.;
TRIPODI A.;
2006-09-15
F K SCHATTAUER VERLAG GMBH
JRC33433
https://publications.jrc.ec.europa.eu/repository/handle/JRC33433,
10.1160/TH06-03-0152,
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