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|Title:||Interaction of Radiolabeled Antibodies with Fungal Cells and Components of Immune System In Vitro and During Radioimmunotherapy of Experimental Fungal Infection|
|Authors:||DADACHOVA E.; BRYAN R.a.; APOSTOLIDIS CHRISTOS; MORGENSTERN ALFRED; ZHANG T.; MOADEL T.; CASADEVALL A.|
|Citation:||JOURNAL OF INFECTIOUS DISEASES vol. 193 p. 1427-1436|
|Publisher:||UNIV CHICAGO PRESS|
|Type:||Articles in periodicals and books|
|Abstract:||The usefulness of radioimmunotherapy (RIT) for infectious diseases was recently demonstrated for several fungal and bacterial infections, but the mechanisms by which RIT is effective against microbes are uncertain. Methods. We investigated the interaction between polysaccharide capsule binding 18B7 monoclonal antibodies (MAbs) labeled with a-emitter 213Bi and Cryptococcus neoformans cells as well as between 213Bi-18B7 and components of immune system, both in vitro and in vivo.|
|JRC Directorate:||Nuclear Safety and Security|
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